1. Epistemology: Bacon is often regarded as the father of empiricism, which holds that all knowledge is derived from sensory experience. Spinoza, on the other hand, believed in rationalism, which holds that some knowledge can be acquired through reason alone.
2. God and Nature: Spinoza believed that God and nature were one and the same, and that everything in the universe was a part of God. Bacon, on the other hand, believed in a God who created and ordered the universe, but who was separate from it.
3. Ethics: Spinoza believed that the ultimate goal of human life was to achieve a state of tranquility and happiness through understanding the nature of the universe and our place in it. Bacon, on the other hand, believed that the ultimate goal of human life was to improve our knowledge and understanding of the natural world, and to use that knowledge to make life better for humans.
4. Methodology: Bacon is known for his scientific method, which involves observation, experimentation, and induction. Spinoza, on the other hand, used deductive reasoning to arrive at his philosophical conclusions.
5. Politics: Spinoza believed in the importance of individual freedom and rejected the idea of a monarchy or aristocracy. Bacon, on the other hand, believed in the importance of a strong central government and the rule of law.

Overall, Spinoza and Bacon had very different philosophical views, with Spinoza focusing on the unity of God and nature, the importance of reason, and individual freedom, while Bacon emphasized the importance of empirical knowledge, the use of the scientific method, and a strong central government.